To evaluate the efficacy and safety of Qingyi Decoction combined with conventional western medicine in the treatment of acute pancreatitis.Methods:We searched PubMed,Embase,Cochrane Library,CBM,CNKI,WanFang) and VIP database,Manual Supplement retrieval important meeting set and Backissues related,by 2 researchers independently screened literature extracted data.Meta analysis with software RevMan5.3 and stata14.Results:A total of 37 RCTs were included in the study,including a total of 3165 patients with acute pancreatitis.Meta analysis results:1）Qingyi Decoction Combined with conventional western medicine in the treatment of acute Qingyi Decoction in improving the efficiency is better than the simple use of conventional western medicine treatment (RR=1.13,95%CI[1.09,1.17],Z=6.59,P<0.00001).2）the QingYi Decoction Combined with routine western medicine treatment can significantly reduce the mortality of patients with acute pancreatitis and the rate of hospitalization time (RR=0.36.95%CI[0.24,0.53],P<0.00001;MD=-5.52,95%CI[-6.20，-4.84],Z=15.93,P<0.00001).3）the combined effect of the amount of MDSAP=-5.99 subgroup SAP the average hospitalization time,the combined effect of the amount of MDMAP=-5.05 subgroup MAP,MDSAP>MDMAP,so Qingyi decoction combined with conventional western medicine in the treatment of severe acute pancreatitis and shorten the hospitalization time with the more obvious effect.Conclusion:Based on current evidence,Qingyi Decoction Combined with conventional western medicine in the treatment of acute pancreatitis can significantly improve the efficiency,reduce the mortality,shorten the hospitalization time,and better effect on severe acute pancreatitis,but need more high quality evidence to further validate this conclusion.