To provide ideas and basis for the further study by learning the current situation on acupuncture-related clinical research published in SCI journals with impact factor over 5 in recent years. Methods:With bibliometrics methods, clinical studies in acupuncture or acupuncture combined with other therapies in the PubMed source database (2010.1.1-2018.5.20) were searched. Quantitative analysis was used to review literature regarding acupuncture with IF more than 5 in science citation index was retrieved since 2010. Results:Altogether 33 papers were collected all over 16 periodicals; The three countries that published the most research was China, the United States, and the United Kingdom and tumors and pain were the most studied diseases. Simple acupuncture was its main intervention and the sham acupuncture group was the most common control setting. Conclusion:From the included literature, the research diseases are expanding and research field from traditional pain to clinical multidisciplinary development. Efficacy and safety are still the focus of current acupuncture research at the same time.