To study the effects of Shenqi Shuyao decoction combined with abdominal acupoint massage on the prevention of constipation of patients with diabetes and craniocerebral injury. Methods:A total of 150 patients with diabetes and craniocerebral injury admitted into the hospital from August 2014 to November 2016 were divided into two groups by registration order. Odd numbers were included into control group (n＝75) and even numbers were included into research group (n＝75). All the patients were given routine nursing. Control group received abdominal acupoint massage, and research group received Shenqi Shuyao decoction combined with abdominal acupoint massage. TCM symptom score, VAS, incidence of constipation, survival quality score and clinical efficacy of two groups were compared and analyzed. Results:Compared with pre-treatment, TCM symptom score and VAS score of two groups significantly decreased after treatment, while scores of physical activity, cognitive function, physical health, psychological health, social relations significantly increased, and above-mentioned indexes of research group were significantly better than control group (P<0.05); 7 d after treatment, the incidence of constipation was significantly lower than that of control group (P<0.05); Clinical total effective rate of research group was significantly higher than that of control group (P<0.05). Conclusion:Shenqi Shuyao decoction combined with abdominal acupoint massage in the treatment of patients with diabetes and craniocerebral injury can significantly increase clinical efficacy, effectively prevent the occurrence of constipation and improve survival quality, which is worthy of generalization.