To observe the effects of Weiyu Yangyin Xieding Formula combined trigeminotherapy on the level of interleukin (IL-17), α-defense and TGF-β1 in patients with Hp positive peptic ulcer.Methods:A total of 96 cases of Hp positive patients with peptic ulcer in our hospital from April 2014 to February were divided into observation group and control group, with 48 cases in each group.The control group was given triple therapy treatment, and the observation group was added Weiyu Yangyin Xieding Formula.Both groups were treated for 8 weeks (antibiotic treatment was only in the initial 2 weeks).Follow-up was performed after 6 months and 12 months after treatment.The wound healing after treatment, the TCM syndromes scores before and after treatment, adverse reactions, Hp clearance rate and recurrence rate, and IL-17, α-defense and TGF-β1 level of two groups were compared. Results:The total effective rate of observation group was 87.50%, which was higher than 70.83% of the control group (P<0.05).The symptoms scores of abdominal pain, acid regurgitation, belching and loose stool of observation group were all lower than those in the control group (P<0.05).The Hp clearance rate of observation group was higher than the control group for 6 months and 12 months after treatment, and the recurrence rate was lower than the control group at 6 months and 12 months after treatment (P<0.05).After treatment, the levels of IL-17 and TGF-β1 of observation group were lower than those in the control group, andα-defensive element was higher than the control group (P<0.05).There was no statistically significant difference between the two groups (P>0.05).Conclusion:Weiyu Yangyin Xieding Formula can effectively regulate the body's immune system, significantly improve the therapeutic effect of Hp positive peptic ulcer, relieve the clinical symptoms, improve Hp clearance rate, and reduce the recurrence rate, which is safe and effective, with high clinical application value.