To investigate the curative effects of integrated traditional Chinese and western medicine treatment of multi-drug resistant tuberculosis and influence on patients' immune function.Methods:A total of 120 cases of multi-drug resistant tuberculosis patients in our hospital from February 2014 to January 2017 were selected and randomly divided into observation group and control group，with 60 cases in each group.The observation group was treated by combining Chinese and western medicine treatment，and the control group was treated only with western medicine.The clinical effect of two groups of patients were observed and compared.Results:After corresponding treatment method for a few months，the total effective rate of observation group was significantly higher than that of the control group，and the differences were statistically significant (P<0.05).After treatment for 4 months，7 months，10 months and 13 months，the lesions absorption of observation group was significantly better than the control group，and the differences were statistically significant (P<0.05).After a period of treatment，the extension of treatment time，turn rate of two groups of patients were increasing，showing that two groups of patients had certain improvement.After treatment for 4 months，7 months，10 months and 13 months，the turn rates of observation group patients were 55.00%，76.67%，86.67%，91.67% respectively.The turn rate of sputum mycobacterium tuberculosis of observation group was significantly higher than that of control group in the same time，and the differences were statistically significant (P<0.05).Conclusion:The syndrome differentiation of traditional Chinese medicine and western medicine diagnosis is used in treating multi-drug resistant tuberculosis.Chinese medicine treats the root causes，and western medicine tends to alleviate the symptoms，and they give full play to their respective advantages and make up for the shortage.The idea of integrated Chinese and western medicine has been popularized.The combined treatment has more significant efficacy than alone treatment.Chinese medicine can improve the body immunity，the centralizer thrift and enhance drug curative effect，and reduce the side effects and complications caused by western medicine treatment，which can significantly improve the absorption rate of lesions，promote the sputum bacteria quickly turn.This view has been widely recognized in clinical practice.