To explore the effects of Duyiwei capsule combined with povidone iodine in the treatment of gingivitis on inflammatory factors and gingival condition. Methods:One hundred and fourteen gingivitis cases selected in our hospital from July 2015 to October 2017 were randomly divided into the observation group and the control group, with 57 cases in each group. The control group was treated with povidone iodine while the observation group additionally treated with Duyiwei capsule. The course of both groups was 15 days. The clinical effects of the 2 groups were statistically analyzed, and the levels of serum inflammatory factors, gingival condition and related biochemical indexes of the 2 groups before and after treatment were compared. Results:The total effective rate of the observation group was 91.23%, which was significantly higher than that of the control group (80.70%) (P<0.05). Compared with that of before treatment, the levels of IL-1, PGE2, CRP and sICAM-1 in gingival crevicular fluid of the 2 groups decreased significantly after treatment, and the observation group was significantly lower than that of the control group (P<0.01). Compared with that of before treatment, the SBI, GI and PLI of the 2 groups decreased significantly after treatment (P<0.01), and the observation group was significantly lower than that of the control group (P<0.05 or P<0.01). Compared with those before treatment, the serum TC and FPG levels of the 2 groups decreased significantly after treatment (P<0.01) of which observation group were significantly lower than that of the control group (P<0.05); The serum LDL and HDL levels of the 2 groups had no significant change before and after treatment (P>0.05). Conclusion:Duyiwei capsule combined with povidone iodine in the treatment of gingivitis can effectively reduce the levels of inflammatory factors in gingival crevicular fluid, improve the gingival condition of patients and play a positive role in the regulation of related biochemical indicators.