To evaluate the effectiveness and safety of “Dog-days Acupoint Application” were applied in patients with coronary heart disease angina pectoris (heart kidney yang deficiency syndrome) clinical curative effect. Methods:A total of 180 cases of coronary heart disease angina pectoris patients with deficiency of heart and kidney yang were randomly divided into general therapy group, acupoint application control group and drug application group, with 60 cases in each group. General treatment group was only given conventional angina treatment; acupoint application control group was given no drugs (starch) application on the basis of general treatment group; drug application group was given Wenyang Huoxue Paste based on the normal control group. The changes of electrocardiogram (ECG), dosage of nitroglycerin and angina symptoms, blood lipid change assessment, plasma fibrinogen concentration, platelet aggregation rate and adverse reactions were observed, and efficacy and safety were analyzed. Results:Compared with normal treatment group, “Dog-days Acupoint Application” Wenyang Huoxue Paste can effectively improve the clinical curative effect, effectively improve the clinical syndrome and angina pectoris and electrocardiogram (ECG) changes, and effectively reduce the nitroglycerin consumption at the same time. Conclusion:“Dog-days Acupoint Application” applied in patients with coronary heart disease angina pectoris (heart kidney yang deficiency syndrome) has certain clinical curative effect.