To evaluate the clinical efficacy and safety of self-made Yiqi Yangyin Huoxue Fang in treating heart qi and yin deficiency and heart vessel and blood stasis syndrome with slow heart beat and frequent premature beat. Methods:Sixty cases of basic heart rate slow and premature beat frequent patients with qi and yin deficiency and heart vessel and blood stasis according to Chinese Medicine syndrome differentiation who were treated in our hospital from July 2017 to March 2017 were randomly divided into treatment group and control group, with 30 cases in each group. The treatment group was given self-made Yiqi Yangyin Huoxue Fang, one dose pre day, twice a day. The control group was treated with Danshen tablets, four tablets each time, three times a day. Course of treatment for two groups was both three months. Dynamic electrocardiogram, traditional Chinese medicine (TCM) syndrome scores, and treatment safety of patients in two groups were observed. Then, the curative effect of arrhythmia and the TCM symptoms after treatment was evaluated. Results:Curative effects on arrhythmia (the total effective rate was 63.34% in treatment group, and 33.33% in control group) in two groups after treatment were significantly different (P<0.05). Treatment group was superior to control group. After treatment, the TCM syndrome scores of the two groups were lower than before treatment, especially in the treatment group (P<0.05). Conclusion:The self-made Yiqi Yangyin Huoxue Fang is safe and effective for the treatment of patients with the qi and yin deficiency and heart vessel and blood stasis syndrome with slow heartbeat and frequent premature beat.