To observe the clinical curative effects of the Zaoshen decoction on diabetic nephropathy and to explore the mechanism of action.Methods:A total of 90 cases of diabetic nephropathy in our hospital during January 2016 to January 2017 included into the research were randomly divided into the control group and the observation group, with 45 cases in each group.Both groups were treated with conventional medical treatment, and the observation group was added “Zaoshen decoction” on the basis of conventional treatment.The treatment continued for 8 weeks.After treatment, the changes of TCM syndrome integrals, blood glucose, renal function, renal artery peak systolic velocity (Vmax), peak diastolic velocity (Vmin), resistance index (RI), and serum anti-aging protein of two groups were compared.Results:1) TCM syndrome integrals of the two groups decreased after treatment, and the downward trend of the observation group was more significant (P<0.05).2) Serum creatinine (Scr), urea nitrogen (BUN), 24 h proteinuria, urinary microalbuminuria (MA), hemoglobin (HbAlc), postprandial 2 hours blood glucose (FPG) were decreased in the two groups after treatment.The decrease of the observation group were more significantly than the control group (P<0.05).3) After treatment, Vmax and Vmin of the two groups were significantly higher than before the treatment, and RI was reduced compared before the treatment.There was statistically significant difference between the observation group and control group (P<0.05).4) Compared with the control group, the “Zaoshen decoction” increased the serum anti-aging protein more significantly, and the differences were with statistical significance (P<0.05).Conclusion:“Zaoshen decoction” can effectively treat diabetic nephropathy, whose mechanism may be related to the up-regulation of serum anti-aging protein.