To investigate the curative effects of Qingxin Wendan Decoction on patients with secondary epilepsy after stroke and effects on serum SOD, MDA and GSH-Px levels. Methods:Seventy six patients with secondary epilepsy after stroke were divided into observation group (n=38) and control group (n=38) according to the envelope method. The control group was treated with diazepam and topiramate for more than 1 year, and the observation group was treated with Qingxin Wendan Decoction for 2 months on the basis of the control group treatment. Curative effect of both groups were evaluated and compared. The serum superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione peroxidase (GSH-Px) and other oxidative stress indicators levels were detected and compared before and after treatment. The relationship between serum oxidative stress index level with curative effect in the observation group were analyzed, and routine blood routine, urine routine, stool routine and abnormal liver and kidney function adverse reactions of two groups were compared. Results:Compared with the control group, the effective rate of the observation group was increased (P<0.05). The Fugl-Meyer score was significantly better than that of the control group (P<0.05). Compared with the control group, after treated for 2 months and 1 years serum SOD and GSH-Px levels in the observation group were increased, while in the same time, serum MDA level in the observation group decreased (P<0.05). Compared with before treatment, after treated for 2 months and 1 years serum SOD and GSH-Px levels in the 2 groups were increased, while in the same time serum MDA level in the 2 groups decreased (P<0.05). Compared with the patients who had ineffective treatment in the observation group, after treated for 2 months and 1 year serum SOD and GSH-Px levels in the patients who had effective treatment in the observation group were increased, while in the same time serum MDA level in the patients who had effective treatment in the observation group decreased (P<0.05). Spearman correlation analysis showed that the serum SOD, MDA and GSH-Px levels in the observation group were closely related to the treatment efficiency (r=0.822,-0.805, 0.874, P<0.05). There were no obvious adverse reactions in the two groups. Conclusion:Based on conventional treatment, Qingxin Wendan Decoction can effectively and safely improve the curative effect and oxidative stress of secondary epilepsy after stroke, and its mechanism may be related to improving oxidative stress in patients.