To study the impact of Cortex Erythrinae decoction for external use on wrist function activities in the Colles fracture. Methods:A total of 60 patients with Colles fracture treated in Traditional Chinese and Western Medicine Hospital of Guangdong Province from Jun 2016 to Jun 2017 were randomly divided into the control group and the observation group, with 30 cases in each group. Patients of both groups were accepted manual reduction and splint external fixation. The demolition of plywood was performed after 5 to 7 weeks and patients carried on the corresponding functional exercise according to patients' recovery. The observation group was combined with 1000 mL Cortex Erythrinae decoction topically on the basis of the above treatment, 1 agent per day. The reexamination with palmar tilt, ulnar inclination angle, and radius shorten of affected side at 1st, 2nd, 4th weeks and at the 3rd months were performed, and wrist function scores, the judge of clinical total effective rate and bone metabolic index changes were observed at the 3rd month. Results:1) The clinical total effective rate of the observation group was 95%, and total effective rate of the control group was 72%. The differences between the two groups have statistical significance (P<0.05, χ2=3.13) 3 months after treatment. 2) Compared with before the reduction, the differences were statistically significant (P<0.05) in palmar tilt, ulnar inclination angle, and radius shorten degree after reduction and clinical healing in the patients of the two groups. The improvement of the observation group was more obvious than the control group (P<0.05). 3) PRWE scores reduced after treatment in both the two groups, and the differences were statistically significant (P<0.05). The falling trend of the observation group was more obvious than the control group, and the differences were statistically significant (P<0.05). 4) The patients in the two groups after treatment, with the content of peripheral blood calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), osteocalcin (BGP), osteoprotegerin (OPG) increased to different extent, while the rising trend of the observation group was more obvious (P<0.05). Conclusion:Cortex Erythrinae decoction for external use can significantly improve the clinical symptoms of Colles fracture and wrist function, and its mechanism may be related to bone metabolism improvement.