To observe the clinical curative effect of Xiangsha Liujunzi Decoction in the treatment of superficial gastritis, and mechanism of the treatment through research and analysis. Methods:A total of 108 cases of chronic superficial gastritis patients in the Department of Gastroenterology in our hospital from February 2015 to February 2017 were randomly divided into treatment group and control group by random number table method, with 54 cases in each group. Two groups were HP positive and treated with triple anti HP therapy. The control group was given Omeprazole Enteric-coated Capsules and Domperidone Tablets oral treatment. The treatment group was added Xiangsha Liujunzi Decoction. TCM symptoms scales, quality of life score assessment, endoscopic grading, clinical curative effect of two groups before and after treatment were recorded, and the NO and SOD in the serum in content were measured for correlation analysis. Results:After treatment, the total effectiveness of treatment group was 87.03%, and the total efficiency of the treatment group was 94.44%. Compared with before treatment, the symptom scores of two groups of patients decreased significantly, and SF-36 increased (P<0.05). Endoscopic mucosal inflammation significantly improved, and endoscopic grading significantly decreased (P<0.05). Serum NO and SOD increased in varying degrees, and the treatment group was better than the control group (P<0.05). The correlation analysis of serum NO, SOD levels and symptom scores of two groups of patients showed that the two had a significant negative correlation. Conclusion:Xiangsha Liujunzi Decoction combined with western medicine is an effective method in treating spleen deficiency type chronic superficial gastritis, and can improve the body SOD, NO level, to improve the gastric mucosal inflammation effect, which is worth popularizing.