To investigate the effects of Yiqi Yangyin Tongluo Sanjie formula (YQYYTLSJF) on patients with early diabetic heart disease. Methods:Sixty three patients with diabetic heart disease were randomly divided into treatment group and control group. The patients of the treatment group took orally YQYYTLSJF and the control group took conventional treatment for eight weeks. The ultrasonic cardiac index, the scores of TCM syndromes and the total points of symptoms of both groups were compared after the experiment. Results:Compared with the control group, the YQYYTLSJF group improved the ultrasonic cardiac index of A/E, AO, LVDs, LVDd, LPW and EF (P<0.05, P<0 .01), relieved the symptoms of chest tightness, chest pain, fatigue, thirst and numbness (P<0.05) after eight weeks treatment. The YQYYTLSJF group effectively reduced the score of TCM symptom (16.55 vs 23.44). Conclusion:YQYYTLSJF can improve the left ventricular diastolic function, improve the clinical symptoms of TCM, and protect hearts of diabetic patients.