To observe the clinical efficacy of Lianhua Qingwen capsule combined with ribavirin aerosol in the treatment of children respiratory syncytial virus infection. Methods:A total of 106 children with respiratory syncytial virus infection treated in our hospital from January 2016 to October 2016 were selected as research objects. All of the children were randomly assigned into observation group and the control group, with 53 children in each group. Children in the control group were treated with ribavirin aerosol, while children in the observation group were treated with Lianhua Qingwen capsule on the basis of the control group. The course of treatment was 7 d. The fever annealing time, cough disappearance time, runny nose disappearance time and nasal obstruction disappearance time were observed. The clinical efficacy was judged after treatment. The levels of serum interleukin-4 (IL-4), interleukin-10 (IL-10), interleukin-12 (IL-12) and interferon-γ (IFN-γ) were detected by electrochemiluminescence immunoassay. Results:The clinical efficacy of the observation group was significantly better than that of the control group (Z=2.253, P<0.05). The fever annealing time, the cough, runny nose and nasal obstruction disappearance time of the observation group was significantly shorter than that of the control group (P<0.05). After treatment, the serum levels of IL-12 and IFN-γ in 2 groups were higher than those before treatment, and the observation group was higher than that of the control group (P<0.05). The serum levels of IL-4 and IL-10 were lower than that before treatment, and the observation group was lower than that of the control group (P<0.05). Conclusion:Lianhua Qingwen capsule combined with ribavirin aerosol has a definite clinical efficacy in fever annealing and improving cough, runny nose and nasal congestion, and can effectively correct the imbalance of Th1/Th2 immune response in children.