To evaluate the therapeutic effect of Huazhi Rugan Granule on nonalcoholic fatty liver disease (NAFLD) with damp heat accumulation. Methods:A total of 120 cases of NAFLD in our hospital were collected and randomly divided into treatment group and control group, with 60 cases in each group. On the basis of non-drug treatment, the two groups were given the oral administration of Huazhi Ligan granules, 3 times a day, one bag each time, and the control group was given Silibinin Capsules, 3 times a day, 8 g each time. The treatment last for 3 months. The clinical symptoms, signs, TCM syndrome, body mass index (BMI), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC) and triglyceride (TG) were compared in the two groups. Results:After treatment, the clinical symptoms, signs, TCM syndrome, BMI, ALT, AST, TC, TG were all lower than before treatment (P<0.05), but the improvement of the treatment group was more obvious than the control group. The difference was statistically significant (P<0.05). During treatment, there was no adverse reaction in the treatment group, and nausea and gastrointestinal reactions occurred in 4 patients in the control group, and rashes occurred in 3 patients. Conclusion:Huazhi Rougan Granule can improve the clinical symptoms, signs, BMI, blood lipid and liver function indexes of the patients with non-alcoholic fatty liver of damp heat and stagnation syndrome, and provide effective treatment for the patients.