To explore the effects of Rhizoma Ligustici Chuanxiong combined with ketorolac tromethamine on the level of oxidative stress in patients with chronic neck and shoulder pain. Methods:The 152 patients with chronic neck and shoulder pain treated in our hospital from February 2017 to February 2018 were randomly divided into two groups according to the digital table method. In the control group, 76 patients were treated with ketorolac tromethamine, and 76 patients in the observation group were treated with Rhizoma Ligustici Chuanxiong on the basis of the control group. The clinical efficacy, pain visual analogue (VAS) score, and present pain intensity (PPI) scores were compared between the two groups. Patients were also analyzed for superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), malondialdehyde (MDA) levels and Barthel score changes. Results:The curative rate and total effective rate were 30.3% and 90.8% in the observation group, which were higher than the control group of 13.2% and 77.6%, respectively, with statistically significant difference (P<0.05). After 2 weeks and 4 weeks of treatment, the levels of VAS score and PPI score were significantly lower in the observation group, which was also lower than that of the control group at the same time, with statistically significant difference (P<0.05). After 2 weeks and 4 weeks of treatment, the levels of MDA were significantly lower in the observation group, which was also lower than that of the control group at the same time with statistically significant difference (P<0.05). After 2 weeks and 4 weeks of treatment, the levels of SOD and GSH-PX were significantly higher in the observation group, which was also higher than that of the control group at the same time, with statistically significant difference (P<0.05). After 2 weeks and 4 weeks of treatment, the levels of Barthel score were significantly higher in the observation group, which was also higher than that of the control group at the same time, with statistically significant difference (P<0.05). Conclusion:Rhizoma Ligustici Chuanxiong combined with ketorolac tromethamine has a good clinical effect on chronic neck and shoulder pain. It has high clinical efficiency, significantly improves the patient's pain state and oxidative stress, and has higher daily life ability. It is worthy of clinical choice.