To investigate the clinical effects of Dihuang Yuling Decoction in the treatment of patients with gouty arthritis and effects on serum inflammatory cytokines.Methods:A total of 104 cases of gouty arthritis admitted to our hospital from December 2015 to March 2017 were randomly divided into the observation group (52 cases) and the control group (52 cases).The control group was treated with western medicine, and the observation group was added DiHuang Yuling Decoction.The two groups were treated for 14 d.The therapeutic effects of the two groups were compared, and the main symptom scores, ESR, serum uric acid and serum inflammatory cytokines were measured before and after treatment.Results:The total effective rate of the observation group (96.15%) was higher than that of the control group (75.00%) (P<0.05).Joint fever, joint swelling, joint pain scores decreased after treatment in two groups (P<0.05); fever, joint swelling, joint pain score of the observation group after treatment were lower than the control group (P<0.05).ESR and blood uric acid decreased in two groups after treatment (P<0.05); ESR and blood uric acid of the observation group after treatment were lower than the control group (P<0.05).IL-1, IL-6 and beta IL-8 decreased in two groups after treatment (P<0.05); IL-1β, IL-6 and IL-8 of patients in the observation group were lower than the control group (P<0.05).Conclusion:The clinical curative effect of Dihuang Yuling Decoction in the treatment of patients with gouty arthritis is significantly, and can reduce the serum inflammatory cytokines IL-1β, IL-6 and IL-8 level with important research significance.