To observe the clinical curative effects of the Quadruple therapy of traditional Chinese medicine in the accumulation and stasis of damp-heat type pelvic inflammatory, and to study some of the action mechanism.Methods:A total of 86 cases of patients with accumulation and stasis of damp-heat type pelvic inflammatory who received and cured during May 2014 to May 2016 in our hospital as the research object, were randomly divided into the control group (42 cases) and the observation group (44 cases).The control group patients received levofloxacin and tinidazole for antimicrobial treatment, and the observation group had the quadruple therapy of traditional Chinese medicine oral and external application, retention enema and far-infrared physiotherapy on the basis of treatment of the control group.Both groups had 30 d for a course of treatment, and 1 year follow-up.Clinical total effective rate and the incidence of sequelae, TCM syndrome integrals, uterine blood flow dynamics and the concentration changes of transforming growth factor beta (TGF-beta) of two groups were compared after treatment.Results:1) The clinical total effective rate of 95.45% in the observation group patients was significantly higher than 83.33% of the control group (P<0.05); After 1 years follow-up, only 1 case of patients with menstrual disorders and 2 cases of increased leucorrhoea in the observation group, 4 cases of menstrual disorders, 6 patients with increased leucorrhea, 1 case of ectopic pregnancy in the control group.The sequela incidences between the two groups were statistically significant (P<0.05);2) Lower abdominal pain, lumbosacral pain and increased leucorrhea, menstrual abnormalities integrals of two groups were less than before treatment (P<0.05).The total symptom integrals also reduced (P<0.05), and the observation group reduced more significantly (P<0.05);3) Uterus peak systole velocity (PSV) of the observation group were significantly higher than the control group after treatment, and the largest pulsation index (PI), vascular resistance index (RI) reduced obviously than the control group.The differences were with statistical significance (P<0.05).4) Peripheral blood TGF-beta level decreased in the two groups after treatment, and the observation group was lower than the control group.The differences were statistically significant (P<0.05).Conclusion:The Quadruple therapy of traditional Chinese medicine has clinical curative effect in patients with the accumulation and stasis of damp-heat type pelvic inflammatory, which is beneficial to reduce the occurrence of sequelae.The mechanism may be associated with the lower expression of TGF-beta.