To explore the effects of Yupingfeng granule combined with conventional western medicine on allergic rhinitis and its influence on ventilatory function and inflammatory reaction. Methods:A total of 86 cases of allergic rhinitis in First Affiliated Hospital of Xinxiang Medical College from May 2016 to March 2018 were selected. According to the different treatment methods, the patients were divided into the control group (the conventional western medicine treatment) and the observation group (conventional western medicine + Yupingfeng granules), with 43 cases in each group. The therapeutic effect, improvement time of clinical symptoms, changes of ventilatory function and inflammatory response were compared between the 2 groups. Results:The total effective rate of the observation group was 81.4% (35/43), and the control group was 74.4% (32/43) (P>0.05). The total effective rate of the observation group was 65.1% (28/43), which was higher than 41.9% of the control group (18/43) (P<0.05), and the improvement time of the clinical symptoms (nasal itching, nasal plug, runny nose, sneezing) in the observation group was obvious, which was shorter than the control group (P<0.05). 2 groups of patients before the treatment of ventilation function and inflammatory response indexes were not statistically significant (P>0.05). After treatment, the maximum expiratory flow rate (PEF) in the observation group was significantly higher than the control group. PEF day and night variation rate was significantly lower than the control group (P<0.05). After treatment, the inflammatory factor interleukins-12 (IL-1) in the observation group was higher than that in the control group. Tumor necrosis factor TNF-(E), immunoglobulin E (IgE) and interleukin-4 (IL-4) were all lower than those in the control group (P<0.05). Conclusion:The combination of Yupingfeng granules and conventional western medicine in the treatment of allergic rhinitis can improve the long-term effect, improve the symptoms of nasal congestion and runny nose, and effectively improve the ventilation function and inflammatory factors of the patients. It is worthy of clinical application.