To observe and analyze the clinical efficacy of acupuncture combined with massage in the treatment of autistic children according to the five elements theory of TCM.Methods:A total of 98 children with autism admitted to the Pediatrics Department of Beijing Massage Hospital from September 2014 to December 2016 were divided into treatment group and control group, with 49 cases in each group.The control group was received rehabilitation training, and the treatment group was treated with acupuncture and moxibustion therapy, and 20 cases of healthy physical examination at the same time were selected as the normal group.CARS, ABC, VABS were assessed in the normal group before treatment, and in treatment group and control group respectively before and after treatment.Blood serum t-PA, PAI-1 levels were detected, and statistical data of each group and clinical curative effect were analyzed.Results:After the treatment, 1) CARS, ABC score of the treatment group and control group was significantly lower than before treatment.VABS score increased significantly (P<0.05), and the improvement of the treatment group was better than control group (P<0.05). 2) t-PA in serum was significantly higher than that before treatment, and the level of PAI-1 was obviously reduced (P<0.05).The treatment group was better than the control group (P<0.05).The treatment group after treatment compared with the normal group, the difference was not statistically significant difference (P>0.05).3) The total effective rate of the treatment group was 85.71%, and the total effective rate of the control group was 73.47%.Conclusion:The five elements of TCM theory under the guidance of massage and acupuncture combined with rehabilitation training, or rehabilitation training treatment can improve the clinical symptoms of children with autism, improve social communication and life self-care ability of children, but the clinical curative effect of TCM five elements theory under the guidance of massage and acupuncture with rehabilitation training is only better than rehabilitation training.