To explore the curative effect of acupoints application in the treatment of patients with rheumatoid arthritis (RA) of dampness-heat obstruction syndrome. Methods:A total of 128 patients with RA selected from January 2016 to January 2017 in our Hospital were divided into observation group and control group according to the random indicator method, with 64 cases in each group. Patients of both groups were given Methotrexate Tablets combined with Leflunomide treatment, and acupoints application was added in the observation group．Changes in symptom score, physicochemical indexes and morning stiffness time in the groups were observed baseline phase and 12 week after treatment. The efficacy and safety of the clinical study were evaluated by calculating efficacy index. Results:The total effective rate of the observation group was higher than that of the control group, with statistically significant difference (P<0.05). The rate of adverse reaction of two groups was basically the same and there was no significant difference (P>0.05). Symptom score, physicochemical indexes and morning stiffness times of two groups were basically the same and there was no significant difference after treatment (P>0.05). After treatment, the scores of joint pressure pain, joint swelling and pain, joint activity, ESR, RF, CPR, LgC and morning stiffness were significantly lower than those in the control group, and the difference was statistically significant (P<0.05). Conclusion:Acupoints application treatment to RA of dampness-heat obstruction syndrome is safe and effective, and it is worthy of clinical application.