To analyze the effect of clinical pharmacists in the intervention of physician pharmacists in clinical pharmacy work. Methods:A total of 3360 patients admitted to the Department of Cardiology in our hospital from March 2013 to November 2017 were selected and their physician orders were reviewed. Among the 1680 patients who received clinical pharmacists' participation in the medical examination and intervention, 1680 were study groups, and 1680 were control groups. A selection of experienced clinical pharmacists and several doctors formed a review team to compare the unreasonable conditions of the two groups of doctors (drug quantity, dose, compatibility, etc.), and analyze the adoption of the doctor's intervention. Results:In the control group, 1320 cases (78.57%) were qualified, and 360 cases (21.43%) were unqualified; 1330 cases (79.17%) passed the intervention before the study group, and 350 cases (20.83%) failed (P>0.05). After the intervention of clinical pharmacists, 290 (82.86%) interventions were adopted and the pass rate was 96.43% (P<0.05). Of these, 314 cases (89.71%) were unreasonable. Antihypertensive drugs and coronary heart disease drugs had the largest number of interventions, with 86 and 52 interventions respectively. Hypoglycemic drugs and cardiac insufficiency drugs had the best intervention effects. Adoption rates were 42/44 (95.45%) and 38/40 (95.00%). The drug irrational problem was mainly caused by missed dose 92/314 (29.30%), inappropriate dose 87/314 (27.71%), improper medication method 68/314 (21.66%), improper cooking method 53/314 (16.88%) and compatibility. Improper 14/314 (4.46%) occurred less frequently. Conclusion:The clinical pharmacists in our hospital have better intervention in the clinical pharmacy work and participate in the examination of medical advice. They can effectively increase the rational rate of medication, and the clinical problems of hypertension and cardiac insufficiency are more prominent. The intervention of these drugs can be strengthened to improve medication rationality.