To review，summarize，analyze and conclude previous research work of replenishing qi and removing blood stasis method and its prescription Shenyuan Yiqi Huoxue Capsule (SYYQ).Methods:The keywords of Shenyuan Dan，Shenyuandan capsule，and Shenyuan Yiqi Huoxue capsule，replenishing qi and removing blood stasis method were used to electronically search in Chinese and foreign biomedical databases such as PubMed，Embase，Web of Science，VIP，CBM，CNKI，Wanfang database，etc.The search period was from establishment to July 20th，2018.A total of 83 related documents were retrieved.After screening and deleting the duplicate and content-independent documents，a total of 42 articles were included.Through literature research，the contents of basis and clinical study of SYYQ were summarized，analyzed and concluded.Results:SYYQ had abundant basic work in the intervention of ischemic heart disease and had a lot of clinical efficacy observation.Conclusion:SYYQ is safe and effective in the treatment of unstable angina pectoris of coronary heart disease.It has abundant basic research achievements in the myocardial protection of ischemia of coronary heart disease and should be further studied.