To evaluate the efficacy of Yiqi Fumai granule after radiofrequency catheter ablation (RFCA) in the patients who had concomitant sinus node dysfunction (SND) and atrial fibrillation (AF).Methods:Twenty-two patients with SND after successful RFCA for AF in our hospital from January 2015 to June 2017 were retrospectively analyzed.18 patients had sinus bradycardia and 6 of them had concomitant sinus pauses.Only sinus pauses occurred in 4 patients.After RFCA，all patients were treated with Yiqi Fumai granule for 8 weeks.After 1-year follow up，recurrence of AF，sinus node function and traditional Chinese medicine (TCM) syndrome were assessed.Results:Early recurrence of AF was occurred in 4 patients，and 3 of them were free of recurrent AF at 2 months after RFCA.21 patients had a significant increase in mean heart rate during 1-year follow-up time.One patient had pacemakers implanted due to serious sinus bradycardia during follow-up time.None patient had sinus pauses ≥3 s.All 22 patients had a drastic reduction of ≥70% in TCM syndrome score during 1-year follow-up time.Conclusion:After RFCA of AF in patients who had concomitant SND and AF，the application of Yiqi Fumai granule can reduce the recurrence of AF，improve sinus node function and improve clinical symptoms.