To observe the changes of related clinical indexes in patients with intense epidemic toxin type of severe hepatitis by artificial liver treatment combined with traditional Chinese medicine decoction, and to analyze its effects on intense epidemic toxin type of severe hepatitis.Methods:A total of 70 cases with intense epidemic toxin type of severe hepatitis admitted in our hospital from September 2014 to February 2016 were randomly selected according to random number table method.All patients were randomly divided into test group and control group.Two groups of patients were received symptomatic treatment.The treatment group was treated with artificial liver support system and traditional Chinese medicine decoction, and the control group was treated with artificial liver support system.All patients were treated for 8 weeks.Fasting blood samples before and after treatment of liver function (ALT, AST, TBil, Alb), electrolyte (Na+, K+), coagulation (PTA) were detected to observe the treatment efficiency and the degree of improvement.Results:After 8 weeks of treatment, Alb and Na+ of two groups showed no significant difference before and after treatment (P>0.05), and ALT, AST, TBil, Alb, K+ and PTA were significantly improved compared with before treatment (P<0.05).The degree of improvement in the treatment group was significantly better than the control group (P<0.05).Conclusion:The liver function of artificial liver support system combined with traditional Chinese medicine in treating patients with intense epidemic toxin type of severe hepatitis, can relieve the clinical symptoms and signs, which is worthy of clinical application research.