To evaluate the effects of Yinzhihuang granules on glucolipid metabolism in the patients with intrahepatic cholestasis during gestation period, and to detect the concentration changes of MRP before and after treatment in placental bile salts transporters.Methods:A total of 60 cases of patients with intrahepatic cholestasis during gestation period from January 2015 to January 2017 were included into the study, and randomly divided into the control group and the observation group, with 30 cases in each group.The two groups of patients had ursodesoxycholic acid and Ademetionine 1, 4-butanedisulfonate, and the observation group had Yinzhihuang granules on this basis.The clinical symptoms, glucolipid metabolic indexes, the pregnancy outcome and the concentration changes of MRP in placental bile salts transporters were compared.Results:1) The itching symptom scores decreased in both the two groups of patients, and the observation group was superior to that of control group (P<0.05); 2) HbAlc, fasting plasma glucose (FPG), triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL-C), low density lipoprotein (LDL-C) were improved to varying degrees in the two groups of patients after treatment, and the improvement of the observation group was more significantly.Compared with the control group, there were statistically significant differences (P<0.05); 3) Neonatal premature birth rate and incidence of neonatal distress in the observation group were significantly inferior to the control group, and the total 24 h postpartum hemorrhage was less than that of the control group.The newborn weight increased than the control group, and the differences were with statistical significance (P<0.05); 4) The concentrations of MRP1 and MRP2 in placenta tissue of the patients in the two groups all up-regulated to some extent after treatment, and the rise trend of the observation group was more obviously (P<0.05).Conclusion:Yinzhihuang granules can significantly improve glucolipid metabolism in the gestation period patients with intrahepatic cholestasis disease, and can promote the illness recovery by up-regulating the concentration of MRP to promote the placenta bile process.