To observe the curative effect of Xiaoke Pill on type 2 diabetic neuropathy and its effect on plasma fibrinogen (FIB) level. Methods:From January 2016 to January 2017, 60 patients with type 2 diabetic neuropathy were enrolled in the study. They were randomly divided into control group and observation group, with 30 cases in each group. Patients in both groups received routine treatment such as hypoglycemic and neurotrophic nerves. The observation group was treated with Xiaoke Pill, 5 pills / time and 3 times / day on the basis of the treatment regimen. A course of treatment was 14 d, and for two courses of continuous treatment with treatment interval 2 d. After the treatment, the levels of HbAlc, postprandial blood glucose 2H (2 hBG), fasting (FBG), FIB, Michigan Screening Scale (MNSI), posterior median nerve (MN) and common peroneal nerve (CPN), as well as the Hamilton Anamiety Scale HAMA score and the Hamilton Depression HAMD scale score were compared after treatment. Results:The levels of HbAlc, 2 hBG, FBG and FIB in both groups decreased after treatment, and the decrease in the observation group was significantly lower than that in the control group (P<0.05). The MNSI scores of both groups decreased after treatment (P<0.05). The levels of MNCV and SNCV in MN and CPN of both groups were significantly higher than those before treatment (P<0.05), and the observation group was significantly better than the control group (P<0.05); The HAMA and HAMD scores of two groups before treatment were similar (P>0.05), and the scores of HAMA and HAMD in the observation group were significantly lower than those in the control group after treatment (P<0.05). The correlation analysis showed that there was a positive correlation between MNSI score and FIB relationship (r=0.189, P<0.05). Conclusion:Xiaoke pills can significantly improve the nerve conduction velocity of type 2 diabetic neuropathy, which can obviously improve the prognosis.