To observe the clinical effects of intravitreal injection of Lucentis combined with Danzhi Xiaoyao Powder oral treatment of neovascular glaucoma, and try to analyze the related mechanism.Methods:A total of 56 cases of neovascular glaucoma (56 eyes) in panzhihua city central hospital from January 2015 to June 2017 were randomly divided into control group and treatment group, with 28 cases in each group.The control group received intravitreal injection of Lucentis for treatment, and the treatment group was added Danzhi Xiaoyao Powder.The visual acuity, intraocular pressure of two groups of patients with neovascularization were observed before and after treatment and after 6 months of follow-up, and the serum VPF and IL-6 levels were observed.The differences of curative effect were analyzed.Results:After treatment, intraocular pressure, visual acuity, neovascularization of two groups were better than those before treatment (P<0.05), and the treatment group was better than the control group (P<0.05).After 6 months of follow-up, IOP and visual acuity and angiogenesis of the treatment group was better than that of the control group (P<0.05).The VPF, IL-6 of two groups were detected after treatment and after 6 months of follow-up, and the VPF IL-6 was significantly lower than the control group, with statistical difference (P<0.05).Conclusion:Danzhi Xiaoyao Powder combined with intravitreal injection of Lucentis is effective in the treatment of neovascular glaucoma.After combined use with traditional Chinese medicine, the recurrence rate is smaller, and it is worthy of clinical application.The effect of the mechanism may be related to the regulation of VPF and IL-6 levels.