To investigate the clinical effect and possible mechanism for treating liver kidney yin deficiency and phlegm blood stasis syndrome diabetic retinopathy patients with Zhujing Pill and Wendan Decoction.Methods:A total of 84 cases From Jun 2016 to Jun 2017 in Rizhao Traditional Chinese Medicine Hospital were randomly divided into the control group of 42 cases and the observation group of 42 cases.Patients in the control group were treated with intravenous drip of alprostadil injection，while patients in the observation group were treated with Zhujing Pill and Wendan Decoction，continuous treatment for 8 weeks.The research was aimed at evaluating the effectiveness by comparing eye index change，observing the hemodynamic parameters before and after treatment of retinal change，and monitoring the levels of serum super oxide dismutase (SOD)，malondialdehyde (MDA)，chemotactic factor (Chemerin) and monocyte chemokine protein-1 (MCP-1).Results:The efficiency of patients in the observation group was 90.5%，which was higher than that of the control group 71.4% (P<0.05).After treatment，the patients in the observation group were significantly lower than those in the control group，such as the thickness of macula，the gray value of the field of vision，the volume of hemangioma，and the area of the blood spot.Hemodynamic parameters in the two groups of patients with retinal CRV，PI，RI were significantly reduced，while the PSV，EDV，Vm levels were significantly elevated.The index change of patients in the observation group was more obvious (P<0.05).The SOD level of oxidative stress in the observation group was significantly higher than that in the control group，while the levels of oxidative stress index MDA and inflammatory indicator Chemerin and McP-1 were significantly lower than that in the control group (P<0.05).Conclusion:The therapy is good to reduce fundus lesions of the diabetic retinal disease and improve the patient's eye microcirculation.Its mechanism may be through regulating oxidative stress indicators in serum SOD，MDA and inflammatory indexes Chemerin and MCP-1 levels to inhibits the retinal oxidative stress response and alleviate the inflammatory damage of retinal tissue，which has certain clinical application promotion value.