To explore the curative effect of Qigui recipe combined with prednisone in the treatment of patients with idiopathic pulmonary fibrosis.Methods:A total of 50 cases of patients with idiopathic pulmonary fibrosis in our hospital were selected and randomly divided into the treatment group (n＝25) and the control group (n＝25).The control group was treated with prednisone，and treatment group was treated with Qigui recipe combined with prednisone.And the following items in the two groups were recorded before and after the treatment：the TCM syndrome score，adverse reaction，six minute walking distance and quality of life score，as well as serum levels of TNF-α and TGF-β1 were detected by enzyme linked immunosorbent assay (Elisa).Results:The total effective rate of the observation group was 84%，which was significantly higher than 76% of the control group (P<0.05).After treatment，the TCM syndrome scores，quality of life scores，TNF-α and TGF-β1 of the two groups were significantly lower than before treatment.The observation group was superior to the control group (P<0.05 or P<0.01).The 6-minute walking distance of the two groups was significantly increased than that before the treatment (P<0.01)，and the difference between the groups was statistically significant (P<0.05 or P<0.01).Conclusion:The combination of Qigui recipe and prednisone is effective in the treatment of idiopathic pulmonary fibrosis patients.It better improved the patient's TCM syndrome，improved exercise endurance and quality of life，adjusted the level of inflammatory factors，improved clinical symptoms.