Effects of Modified Sanhuang Decoction on Polycystic Ovaries,Endocrine and Metabolism in the Patients with Polycystic Ovarian Syndrome of Phlegm-damp Accumulated with Heat Syndrome
To observe the clinical curative effect of the Sanhuang decoction on phlegm-damp accumulated with heat type polycystic ovarian syndrome,and to evaluate the impact on polycystic ovaries,the levels of endocrine and metabolic capacity.Methods:A total of 50 patients with polycystic ovarian syndrome in our hospital from January 2013 to December 2016 were included into the study and randomly divided into the control group and the observation group,with 25 cases in each group.The control group had oral ethinylestradiol cyproterone for 3 courses of treatment.The observation group had Sanhuang decoction based on the basic treatment of the control group,1 agent/d,taken 200 mL with warm water in the morning and evening.Syndrome integral changes and polycystic ovarian changes of the two groups before and after treatment were observed.The follicle-stimulating hormone (FSH),luteinizing hormone (LH) and testosterone (T),estradiol (E) content changes,and glycosylated hemoglobin (HbAlc),fasting insulin (FINS) and insulin resistance index (HOMA IR),visifatin (VF),leptin (LEP),adiponectin (APN) content changes of the two groups before and after treatment were compared.Results:1) After treatment,the clinical effective rate of observation group was 76%,which was superior to 36% of the control group (χ2=3.19,P<0.05); 2) TCM syndrome integrals decreased in both groups compared with before treatment,and the differences were statistically significant (P<0.05).The observation group decreased more significantly (P<0.05); 3) The ovarian volume and number of follicles in patients of two groups after treatment declined than before the treatment (P<0.05).The observation group was superior to that of control group (P<0.05); 4) Compared with that before treatment,the levels of FSH,LH,and T all decreased in two groups of patients after treatment,and the concentration of E increased.The differences had statistical significance (P<0.05).The improvement extent of observation group was obviously greater than the control group.The differences were statistically significant (P<0.05); 5)HbAlc,FINS and HOMA-IR all reduced in the two groups after treatment.The differences were statistically significant compared with before treatment (P<0.05).The observation group was superior to that of control group (P<0.05); 6) Compared with before treatment,VF,LEP levels of the two groups of the patients decreased after treatment.The concentration of APN increased.The differences were statistically significant (P<0.05),and the improvement of observation group was more obviously than the control group.The differences were statistically significant (P<0.05).Conclusion:Sanhuang decoction can obviously improve clinical symptoms of polycystic ovarian syndrome with phlegm-damp accumulated with heat syndrome and ovarian abnormal morphology,can simultaneous adjust the endocrine and metabolic ability.