To investigate the effect of Yiqi Huoxue Yangyin Method on the quality of life and immune function of patients with advanced esophageal cancer after radiochemotherapy.Methods:The 144 patients with advanced esophageal cancer treated in our hospital between January 2017 and March 2018 were randomly divided into two groups according to the digital table method，with 72 cases in each group.Both groups of patients received radiochemotherapy，and the control group received conventional supportive therapy.The observation group was supplemented with Yiqi Huoxue Yangyin Method on the basis of the control group.The differences in immune function and quality of life were compared between the two groups，and the scores of medical symptoms，hemoglobin and albumin levels were analyzed.Results:After 4 weeks and 8 weeks of treatment，the levels of CD3+，CD4+ and CD8+ were increased in the observation group，which was also higher than that in the control group at the same time.The difference was statistically significant (P<0.05).After 4 weeks and 8 weeks of treatment，the quality of life scores in the observation group were increased，which was also higher than that in the control group at the same time.The difference was statistically significant (P<0.05).After 4 weeks and 8 weeks of treatment，the TCM syndrome score was decreased in the observation group，which was also lower than that in the control group at the same time.The difference was statistically significant (P<0.05).After 4 weeks and 8 weeks of treatment，the hemoglobin and albumin levels in the observation group were increased，which were also higher than that in the control group at the same time.The difference was statistically significant (P<0.05).Conclusion:Yiqi Huoxue Yangyin Method has good clinical effects on patients with advanced esophageal cancer after radiochemotherapy.It can effectively improve the quality of life and immune function of patients，improve their clinical symptoms and nutritional status，and is worthy of clinical selection.