To investigate the curative effect of Chinese herbs combined with conventional western medicine treatment and the effect on the electrical activity of the brain.Methods:A total of 108 patients with epilepsy in our hospital from January 2013 to October 2016 were treated.According to random table method，they were randomly divided into treatment group (Gualou Guizhi Decoction combined with western medicine treatment) and control group (conventional western medicine therapy)，with 54 cases in each group.The clinical curative effects，the seizure frequency，EEG，quality of life and adverse reactions of two groups were observed.Results:The clinical curative effect of traditional Chinese medicine group was better than the control group (P<0.05).The seizure frequency at different time in the traditional Chinese medicine group after treatment was lower than the control group (P<0.05).EEG frequency relative power variation in the traditional Chinese medicine group was better than the control group after treatment (P<0.05).The occurrence rate of adverse reactions of traditional Chinese medicine group was lower than the control group (P<0.05).The quality of life of traditional Chinese medicine group was better than the control group (P<0.05).Conclusion:The effects of Gualou Guizhi Decoction combined with western medicine therapy for patients with epilepsy should be affirmed，which can reduce seizure frequency，the incidence of adverse reactions，improve the electrical activity of the brain，improve the life quality of patients.