To explore the curative effect of replenishing the lung and kidney and resolving phlegm and blood stasis method in treating acute exacerbation of chronic obstructive pulmonary disease.Methods:A total of 100 cases of patients with acute exacerbation of chronic obstructive pulmonary disease in our hospital from February 2016 to September 2017 were randomly divided into observation group and control group, with 50 cases in each group.The control group was treated with western medicine, and the observation group was added replenishing the lung and kidney and resolving phlegm and blood stasis method.The treatment effect of two groups was compared.Results:The observation group was superior to the control group, and the difference was statistically significant (P<0.05) in the comparison between the two groups of patients before and after treatment, TCM syndrome, FEV1%, FEV1/FVC/ %.Before treatment, the serum il-10, il-13, il-18, tnf-alpha and CRP content of the two groups were relatively small, with no statistical significance (P>0.05).After treatment, the content of serum il-13, il-18, TNF-alpha and C RP decreased significantly, and the content of il-10 was significantly increased, and the difference was statistically significant (P<0.05).There were statistically significant differences between groups (P<0.05).Conclusion:For the use of traditional Chinese medicine of replenishing the lung and kidney and resolving phlegm and blood stasis method, and combined western medicine, can achieve a good therapeutic effect on the patients with acute exacerbation of chronic obstructive pulmonary disease, and has a certain effect on improving the therapeutic effect and improving the living standard.