To investigate the colon cancer inhibition of modified wumei boluses and to analyze some of the action mechanism. Methods:A total of 30 BALB/c male mice were randomly divided into blank group, model group and wumei boluses group, with 10 in each group. The mice of blank group did not accept intervention measures, and wumei boluses group had lavage treatment of wumei boluses decoction. Blank group and model group received isodose physiological saline lavage. All the groups had 28 d intervention. The changes of tumor volume, weight of mice and survival rate, concentration changes of Wnt, JNK in the tumor tissue were observed. Results:1)the mice tumor volume increased in the model group and wumei boluses group than before the intervention, and the increase in the wumei boluses group was more slowly. The tumor tissue had a tendency to decrease after 28 d of intervention. 2)After 28 days of the intervention, the mice weight in the blank group was similar to the initial weight, and the mice weight of the model group and the wumei boluses decreased obviously. The decrease of model group was more significantly than that in the wumei boluses group (P<0.05); After the intervention, only 4 mice survived in the model group, and 7 mice survived in the wumei boluses group. The survival rate differences between the two groups were statistically significant (P<0.05). 3)Protein and mRNA of Wnt, JNK in mice tumor tissue of both the model group and wumei boluses group showed high expression, and expression levels of Wnt, JNK in the model group was obviously higher than that of wumei boluses group (P<0.05). Conclusion:The modified wumei boluses has obvious inhibitory effect on deterioration of colonic adenoma, and the mechanism of antitumor may related to the inhibition on the expression of Wnt pathways.