To discuss the therapeutic effects of warming needle moxibustion and tuina combined with herbal fomentation in the treatment of patients with knee osteoarthritis. Methods:One hundred and seventy eight patients with knee osteoarthritis selected from January 2016 to December 2016 in our hospital by the random indicator method were divided into the observation group and the control group, with 89 cases in each group. Two groups were received warming needle moxibustion and tuina treatment, and the observation group additionally received herbal fomentation treatment. Therapeutic effect criterion, visual analogue scale (VAS) and Lequesne index were used as an evaluation tool, and the incidence condition of adverse reaction in both groups were observed. Results:The effective rate of the observation group was higher than the control group, with statistical significant difference (P<0.05). And the adverse effects rate of both groups were basically the same, and there was no significant difference (P>0.05). Baseline phase, VAS score and Lequesne index of two groups was basically the same, and there was no significant difference (P>0.05); Posttreatment, VAS score and Lequesne index of observation group was lower than the control group, with statistical significant difference (P<0.05). Conclusion:Warming needle moxibustion and tuina combined with herbal fomentation in the treatment of knee osteoarthritis is safe and effective, which is worthy of clinical application.