To investigate the immunological activity of polysaccharides from fermented Cordycepssinensis powders.Methods:Polysaccharides from fermented Cordycepssinensis powders were obtained through water extraction and alcohol precipitation,reconstitution,dialysis,concentration and freeze-drying,named after CSMP-60.Its extraction conditions：60 ℃ water extraction,extraction time 4h,solid-liquid ratio 1:15,the number of extractions 2 times.The immune activity of CSMP-60 was measured using mouse immune cells.Results:CSMP-60 could promote the proliferation of spleen cells (P<0.05),and significantly promote the secretion of TNF-α from mouse peritoneal macrophages (P<0.05).It has a tendency to promote the secretion of IFN-γ by spleen cells.Conclusion:CSMP-60 may be one of the immunocompetence substances of fermented Cordycepssinensis powders.