To discuss the role of typical prescriptions of proprietary Chinese medicines in the rational use of drugs and to provide a basis for clinical rational drug use.Methods:A total of 890 prescriptions of proprietary Chinese medicines issued by the hospital from May 2017 to July 2017 were selected as research objects，and prescriptions of proprietary Chinese medicines were divided into control group according to time points (n＝454，May 2017-June 2017 ) and observation group (n＝436，June 2017-July 2017).The control group did not comment on the prescriptions of proprietary Chinese medicines.The observation group commented on the pharmacy that issued the proprietary Chinese medicines，and recorded and counted prescription medication over the course of treatment，repeated administration，unreasonable combination and discrepancies in medication，and recorded the occurrence of two unreasonable drug disputes.A self-made questionnaire was used to evaluate the prescription pharmacology，nature and flavor，channel tropism，the compatibility and the dose and course of treatment of the two groups of prescription doctors.The rational use of the two groups of drugs and typical cases were compared.Results:A total of 32 prescriptions were found to be unreasonable in the observation group，accounting for 7.34%，which was lower than the control group of 53 prescriptions，accounting for 11.67% (P<0.05).In the observation group，the prescriptions，repeated medications，medication inconsistencies，incompatibility contraindications，and medication contraindication rates were lower than those in the control group (P<0.05).There was no significant difference in the incidence of non-standard prescriptions between the two groups (P>0.05).After prescription reviews，the incidence of disputes due to the irrational use of drugs in the observation group was lower than that of the control group (P<0.05).The pharmacological action，nature and flavor，channel tropism，compatibility，dosage and course of treatment were all higher in the observation group than in the control group (P<0.05).Conclusion:The prescription of proprietary Chinese medicines plays an important role in the rational use of proprietary Chinese medicines.It is helpful to reduce the incidence of unreasonable use of medicines，reduce disputes over medication and improve the doctors' ability to use traditional Chinese medicines.It is worthy of promotion and application.