The proposal of neurovascular unit(NVU)has changed the idea that pure rehabilitation of brain blood supply is the key to the treatment of neuron damage after a stroke which makes people realize that the brain injury induced by ischemic stroke is a complex pathological process.It involves the various components of NVU,and nerve protection goals should expand into a comprehensive protection of multiple components from a single neuron protection.Drug protection should target at all kinds of harmful factors in pathological process.The identification of comprehensive protection would allow the treatment of ischemic stroke to achieve ideal effects.The traditional Chinese medicine has the advantages and characteristics of multi-component,multi-target,multi-link and multi-channel protection and overall regulation,which is in line with the requirements of the treatment strategy of neurovascular unit.Based on neural vascular unit,this paper reviewed the research progress of traditional Chinese medicine treatment of ischemic stroke in order to provide certain reference for follow-up treatment of traditional Chinese medicine clinical research and treatment of ischemic stroke.