According to the definition of sepsis 3.0,sepsis is multiple organ failure caused by uncontrollable reaction to infection.Sepsis-associated encephalopathy (SAE) is diffuse brain dysfunction caused by non-injection disease.It has many patterns of manifestation,such as obnubilation,irritation,delirium,coma,and so on.And it is common that many patients remaining hypomnesis in their recovery period.Although the pathogenesis and diagnostic criteria of SAE are still unknown,traditional Chinese medicine has advantages in treating SAE for it can prescript different medicine according to different symptoms and stages of the disease.However,traditional Chinese medicine is poor in scientific research,so it is urgently needed to research the pathogenesis of SAE and seek more evidence.