To study the effects of Resuqing Granules combined with amoxicillin in the treatment of exogenous fever and the influence on inflammatory reaction.Methods:A total of 78 patients with exogenous fever in Anhui Provincial Hospital from January 2016 to December 2017 were selected and divided randomly into control group and study group,with 39 cases in each group.Control group was treated with amoxicillin conventional therapy,and study group was treated with Resuqing Granules combined with amoxicillin,and the therapeutic effect evaluation of 2 groups were carried out 72 h after continuous treatment.The clinical effects in 2 groups after treatment were calculated.The improvement of clinical symptoms,the body temperature and serum inflammatory reaction index levels in 2 groups before and after treatment were compared; the occurrence of adverse reactions in 2 groups during the treatment were calculated.Results:Compared with before treatment,the total scores of primary symptoms,secondary symptoms and traditional chinese medicine (TCM) symptoms decreased significantly in 2 groups 72 h after treatment,and the score of study group was lower than that of control group (P<0.01); the antifebrile effect time and completely antifebrile time in study group were shorter than those in control group (P<0.01); the clinical total effective rate in study group 72 h after treatment reached up to 94.87%,which was higher than 61.54% in control group (P<0.01); compared with before treatment,the body temperature and serum CRP levels in 2 groups 12-72 h after treatment decreased gradually (P<0.01),and the body temperature in study group of 24 h,48 h,and 72 h after treatment were lower than those in control group (P<0.05 or P<0.01),and the serum CRP levels in study group of 48 h and 72 h after treatment were lower than those in control group (P<0.01); there was no severe adverse reactions in 2 groups during treatment.Conclusion:Resuqing Granules combined with amoxicillin can improve the clinical symptoms of exogenous fever patients effectively,reduce the body temperature of patients quickly,and inhibit the body inflammatory reaction and has good security,and the clinical effect is better than using amoxicillin alone.