To investigate the effect of Fuzheng Guben Decoction on synergistic attenuation and immune function of patients with locally advanced cervical cancer undergoing concurrent chemoradiotherapy.Methods:A total of 81 cases of patients with locally advanced cervical cancer in Weinan Maternity and Child Health Care Hospital from January 2013 to January 2016 were selected and divided into control group (n＝40,concurrent chemoradiotherapy only) and observation group (n＝41,concurrent chemoradiotherapy combined with oral administration of Fuzheng Guben Decoction).The clinical efficacy,occurrence of adverse reactions and immune function were compared between the two groups.Results:After treatment,the total effective rate of the observation group were significantly higher than that of the control group (78.05% vs 60.00%) (P<0.05); The incidence of leukopenia,the total adverse reactions to thrombocytopenia,and gastrointestinal Ⅲ-Ⅳ reactions of the observation group were significantly lower than that of the control group (P<0.05).Liver function injury,chronic radiation enteritis,and chronic radiation cystitis showed a decreasing trend compared with the control group,but the difference was not statistically significant (P<0.05); The differences in the levels of CD3+,CD4+,CD8+ and CD4+/ CD8+ before treatment were no significant between two groups (P>0.05); After treatment,the levels of CD3+,CD4+,CD8+ in both groups were significantly lower than before treatment (P<0.05).However,the CD3+ and CD4+ levels and CD4+/ CD8+ values of the observation group were significantly higher than that of the control group (P<0.05),and CD8+ levels were significantly lower than in control group (P<0.05).Conclusion:Oral administration of Fuzheng Guben Decoction can significantly improve the short-term clinical efficacy of concurrent chemoradiation in patients with locally advanced cervical cancer,reduce the adverse reaction,and enhance the patients' immune function.