To investigate the effects of Modified Zhuanggu Decoction combined with calcium on bone mineral density and bone metabolism biochemical indicators in patients with osteoporosis.Methods:A total of 132 patients with osteoporosis treated in People's Hospital of Dazhou District from January 2016 to July 2017 were selected and randomly divided into control group and an observation group,with 66 cases in each group.Patients in the control group were treated with allenphosphonic acid sodium and calcium D3 pills,and patients in the observation group were given Modified Zhuanggu Decoction.The clinical efficacy was compared,and the levels change of bone mineral density and bone metabolism biochemical indicators were monitored.Results:The clinical efficacy rated in the observation group was 90.9%,which was significantly higher than that of the control group 78.8% (P<0.05).The TCM syndrome integrals in the observation group were decreased more than that of the control group (P<0.05).The femoral neck and L2-L4 vertebrae bone mineral density in the observation group were increased more than that of the control group (P<0.05),and the levels of serum calcium and osteocalcin increased more than that of the control group,while the levels of β-CTX and alkaline phosphatase were decreased more than that of the control group (P<0.05).Conclusion:Modified Zhuanggu Decoction can effectively improve the patients' bone mineral density and promote bone formation,which has outstanding anti-osteoporosis effect,which is worthy of further research and development.