To observe the effect of Tianwang Buxin Pill on heart and kidney function in patients with cardio-renal syndrome, and to explore its intervention effect on BNP concentration. Methods:Sixty patients with cardio-renal syndrome admitted to the First Affiliated Hospital of Henan University of Traditional Chinese Medicine from January 2014 to December 2015 were randomly divided into control group and observation group according to the order of admission, 30 cases in each group. The patients in both groups were treated with conventional drug treatment in the Department of Nephrology. The observation group was treated with Tianwang Buxin Pill on the basis of routine treatment. The two groups were treated with 4 weeks as a course of treatment. After the treatment, the change of two groups were compared in terms of the total effective rate, TCM syndrome score, cardiac function indicators and renal function indicators. Results:1) After treatment, the total effective rate of the observation group was significantly higher than that of the control group, and the score of TCM syndrome was also lower than that of the control group. The difference of the two indexes was statistically significant (P<0.05). 2) The renal function indexes of the two groups after treatment: 24 h Upro, Uβ2-MG, SCr, BUN and UAER were better than before treatment, and the observation group improved more significantly (P<0.05). 3) After 4 weeks of treatment, the cardiac function of the observation group was significantly improved compared with the control group (P<0.05). 4) The concentration of BNP in the two groups decreased significantly after treatment, and the observation group decreased more significantly (P<0.05). Conclusion:Tianwang Buxin Pill can significantly improve the heart and kidney function of patients with cardio-renal syndrome. The change of BNP concentration can effectively evaluate the curative effect.