To investigate the effects of Cucumis melo L extract injection on coagulation function and trauma index of limb fracture.Methods:From May 2016 to May 2017,a total of 172 patients with limb fractures treated in Affiliated Hospital of Qinghai University were selected and randomly divided into control group (n＝85) and observation group (n＝87) according to the random number table method.All subjects underwent conventional external fixation and external fixation.The control group was treated with Qigu capsule and the observation group was treated with Cucumis melo L extract injection.The changes of trauma index,coagulation function index and functional independence assessment (FIM) before and after treatment were observed,and the side effects were recorded.Results:After the treatment,the trauma index such as CK (43.62±3.45) U/L,LDH (232.42±11.05) mmol/L,CKMB (26.10±2.41) U/L,GOT (31.19±2.89) U/L,GPT (28.27±3.19) U/L,D-D (177.52±12.56) μg/L in observation group were decreased more significant than those of the control group (P<0.05).In observation group,the FIB (3.42±0.34) g/L,PLT (171.19±14.74)×109/L,PT (33.81±3.10) s were increased more significantly than those of the control group,APTT (32.52±2.56) s,TT (15.27±2.47) s were decreased significantly than those of the control group (P<0.05).In observation group,after the treatment,the FIM (111.84±5.19) score was significant higher than the control group (98.35±4.67) (P<0.05).After the treatment,there was no significant difference in total side effect rate between the observation group (3.45%) and the control group (8.24%) (P>0.05).Conclusion:For the patients with limb fracture,Cucumis melo L extract injection can effectively improve the recovery of coagulation function and promote wound healing.