To analyze serum differential metabolic components in Uyghur medical treatment in patients with psoriasis. Methods:The serum of psoriasis patients and healthy volunteers from Hospital of Xinjiang Traditional Uyghur Medicine from April 2014 to October 2015 were selected. The differential metabolic components of serum from healthy volunteers and patients with psoriasis were analyzed by 1H-NMR technique combined with orthogonal partial least squares method. Results:Compared with healthy volunteers group, VLDL, LDL, unsaturated lipid, glycoprotein, tyrosine, histidine, acetone of serum in psoriasis patients group were decreased and serum lactic acid, creatine, formic acid, acetic acid, phenylalanine were increased. The difference was statistically significant (P<0.05). Conclusion:Psoriasis patients still have amino acid, lipid and some small molecules metabolic disorder by combined treatment of Uyghur Medicine.