To investigate the clinical efficacy and mechanism of Lugua Polypeptide in treating patients with traumatic thoracolumbar fractures.Methods:From April 2014 to April 2017,a total of 167 patients with traumatic thoracolumbar fractures treated in Affiliated Hospital of Qinghai University were selected and divided into the control group (n＝82) and the observation group (n＝85) according to different treating methods.The control group was treated with risedronate sodium alone,and the observation group was treated with risedronate sodium combined with Lugua Polypeptide.The changes of stress response index such as Cor,NE,ALD,bone metabolism BGP,PTH,BALP,C1CP and living ability were compared before and after treatment.Results:In the observation group,the BALP (26.92±2.67) pg/mL was increased more significantly than that of the control group,and the CTX (0.33±0.14) mg/mL,BGP (5.71±1.25) μg/L,P1NP (47.33±4.14) mg/mL,PTH (31.38±3.17) pg/mL and C1CP (7.07±0.91) μg/L were decreased more significantly than those of the control group (P<0.05).In observation group,the AngⅠ (3.38±0.46) pg/mL,E (71.46±3.71) ng/mL,ALD (96.92±5.38) pg/mL,AngⅡ (31.47±2.75) pg/mL were decreased more significant than those of the control group.NE(96.71±4.64) ng/mL,Cor(278.87±12.57) nmol/L were significantly than those of the control group (P<0.05).After the treatment,the total score of Barthel index after treatment in the observation group (43.34±4.15) was significantly higher than that of the control group (30.83±3.04) (P<0.05).The total effective rate was 92.94% in the observation group and 73.17% in the control group,and there was significant difference between the 2 groups (P<0.05,χ2=3.38).Conclusion:For the repair treatment of bone tissue in patients with traumatic thoracolumbar fracture,Lugua Polypeptide can be used as an auxiliary drug.It can reduce stress response,promote bone metabolism and provide life ability for patients.