To observe the clinical efficacy of Shaoyao Gancao decoction combined with nimodipine in the treatment of diabetic peripheral neuropathy, and to investigate the effects on electrophysiological characteristics of diabetic peripheral neuropathy.Methods:A total of 120 cases of lower extremity in patients with type 2 diabetes peripheral neuropathy hospitalized in our hospital from April 2009 to November 2015 were randomly divided into observation group and control group.And 60 cases of type 2 diabetes hospitalized patients without peripheral neuropathy with lower extremity were included in the diabetic group.The diabetic group received the basic treatment of diabetes, and the control group was given nimodipine on the basis of the diabetic group.The observation group was treated with Shaoyao Gancao decoction on the basis of the control group.Fasting plasma glucose (FBG), postprandial 2H blood glucose (2 hPBG), glycosylated hemoglobin (HbAlc), ankle brachial index (ABI), and electrophysiological examination by professional physicians were recorded.Results:1) After treatment, FBG, 2 hPBG and HbAlc were significantly different (P<0.05), in which the expression levels of FBG, 2 hPBG and HbAlc in the observation group were lower than those in the control group and diabetes group (P<0.05).2) After treatment, the ABI observation group and the control group were higher than before treatment (P<0.05), and the observation group was superior to the control group (P<0.05) and the diabetes group (P<0.05).3) After treatment, the latency and amplitude of SSR decreased in the observation group and the control group (P<0.05), and the decrease in the observation group was better than that in the control group (P<0.05) and the diabetes group (P<0.05).4) Before treatment, the NCV in the observation group and the control group were lower than that in the diabetic group (P<0.05).After treatment, the NCV in the observation group and the control group increased (P<0.05), and the observation group was better than the control group (P<0.05).Conclusion:Shaoyao Gancao decoction combined with nimodipine in the treatment of diabetic lower extremity peripheral lesions can improve the blood glucose level of ABI and lower limb function, while improving its SSR and NCV nerve electrophysiological characteristics, with certain clinical reference value.