To explore the effects of Shugan Hewei Jiangni Decoction on protease activated receptor-2(PAR2)and Cyclooxygenase-2(COX-2)protein in patients with gastroesophageal reflux disease(GERD)and with disharmony between liver and stomach syndrome.Methods:A total of 178 patients with GERD were selected,from January 2011 to January 2016 in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,as the research subjects.And they were randomly divided into the observation group and the control group,with 89 cases in each group.Patients of the two groups were both given with Omeprazole Enteric-coated Tablets for the treatment.And Shugan Hewei Jiangni Decoction was added in the observation group.Changes in symptom score of Reflux diagnostic questionnaire(RDQ),esophageal mucosal of PAR-2 and COX-2 protein in the two groups were observed at baseline phase and 12 week after treatment.Results:During the baseline phase,symptom score of RDQ,esophageal mucosal of PAR-2 and COX-2 protein in the two groups was basically the same.And there was no significant difference(P>0.05); After treatment,symptom score of RDQ,esophageal mucosal of PAR-2 and COX-2 protein of the observation group was significantly lower than control groups,and it was statistically significant(P<0.05).Pearson correlation coefficient showed that symptom score of RDQ in the observation group were positive correlated with esophageal mucosal of PAR-2 and COX-2(P<0.05),while symptom score of RDQ in the control group were not correlated with esophageal mucosal of PAR-2 and COX-2 protein esophageal mucosal of PAR-2(P>0.05).Conclusions:Omeprazole Enteric-coated Tablets combined with Wenyang Huoxue Decoction has good efficacy in treating gastroesophageal reflux disease and disharmony between liver and stomach syndrome.The mechanism may be associated with reducing patients' esophageal mucosal of PAR-2 and COX-2 protein,to get clinical efficacy.