To investigate the clinical efficacy of Qingre Liangxue Huayu Decoction combined with alteplase intravenous thrombolysis on acute cerebral infarction.Methods:A total of 108 patients with acute cerebral infarction treated in Huanghua People's Hospital from June 2013 to December 2015 were selected and divided into observation group and the control group,with 54 cases in each group.Patients in the control group were given alteplase intravenous thrombolysis.Based on the same treatment,patients in observation group were given Qingre Liangxue Huayu Decoction.National Institutes of Health Stroke Scale (NIHSS) score and Barthel index were compared between 2 groups before and at the 5th day,10th day after treatment.The hospitalization days and clinical efficacy were compared between the 2 groups.Results:There were no significant differences in the baseline data,NIHSS score and Barthel index before treatment between the 2 groups (P>0.05).The NIHSS score in the observation group was significantly lower than that in the control group at the 5th day,10th day after treatment,and the difference was statistically significant (P<0.05).The Barthel index in the observation group was significantly higher than that in the control group at the 10th day after treatment,and the difference was statistically significant (P<0.05).The hospitalization days of observation group was significantly less than that of control group,and the difference was statistically significant (P<0.05).The clinical efficacy and total effective rate of the observation group were significantly better than the control group,and the difference was statistically significant (P<0.05).Conclusion:Qingre Liangxue Huayu Decoction combined with alteplase intravenous thrombolysise had obvious curative effect on acute cerebral infarction,and it could significantly accelerate the recovery of neurological function and shorten the hospitalization time,which is worthy of clinical application.